Biocatalysis
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Home | 服务与解决方案概览 | Drug Substance | Enabling Technology Platform | Biocatalysis
Biocatalysis, involving the use of natural catalysts such as enzymes, offers environmentally friendly and cost-effective alternatives to traditional chemical synthesis . Especially when the reactions involve chiral molecules, biocatalysis provides highly stereoselective biotransformations, or efficient resolutions of enantiomers.
WuXi STA’s comprehensive biocatalysis platform offers a one-stop solution for all of your biocatalysis challenges; this includes enzyme screening, enzyme evolution, enzyme fermentation as well as process development and production.
Capability and Capacity
- Experience with 20+ common biocatalysis reaction types
- 10+ commercial projects, 300+ processes developed
- A large in-house library including 2,500+ enzymes and 200,000+ variants
- A number of Biocatalysis laboratories that can handle 10-15 projects simultaneously
- Totally 17,000 L of fermenter volume, the largest fermenter 2,000 L
Related Resource
20 Common Enzymatic Reactions
- Aminotransferase (ATA)
- Ketoreductase (KRED)
- Imine Reductase (IRED)
- Hydrolase/amidase
- Esterase/Lipase
- Glycosyltransferases
- Epoxidase and Halohydrin Dehalogenase (HHDH)
- Nitrilase (NIL)
- Nitrile Hydratase (NHase)
- Hydroxynitrilelyase (HNL)
- Monoamine Oxidase (MAO)
- Enoate Reductase (ERED)
- Transketolase (TK)
- Deoxyriboaldolase (DERA)
- Nitroreductase (NTR)
- Cyclohexanone Monooxygenase (CHMO)
- Baeyer Villager Monooxygenase (BVMO)
- Cytochrome P450 Monooxygenase (CYP)
- Nucleoside, Nucleic Acid, Oligonucleotide, sgRNA
- Unnatural Amino Acid, Dipeptide, Polypeptide
Case Study：3-fold Yield for a key RSM after Enzyme Evolution
The RSM molecule is a key chiral RSM for a late-stage API. We use our proprietary enzyme to improve the yield to 3 fold.
| Original Route | 5 step reactions | Yield=30% (5 steps) | PMI > 100 |
| Enzymatic Route | 2 step reactions with WuXi STA proprietary enzyme* | Yield=90% (2 steps) | PMI < 20 |
* About Enzyme Evolution of Transaminase
- Natural enzyme conversion <2%
- Evolved enzyme conversion >95% after 2 rounds of evolution
