Flow Chemistry
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Through partnerships with our clients, WuXi STA has established an industry-leading flow chemistry (continuous manufacturing) platform offering process development, non-GMP, and GMP production services for projects from pre-clinical to commercial stage. Taking advantages of our rich experience built on hundreds of projects, and the modularization of our multi-purpose flow chemistry lines, we are able to offer quick and economically viable solutions to encounter process challenges in conventional batch mode.
Currently, we have 26 flow chemistry lines at Shanghai Jinshan, Changzhou and Changshu sites in China.
Selected Reactions in Our Flow Chemistry Toolbox
- Low Temperature Metallo-Organic Reactions
- High Temperature/Pressure Reactions
- Ozonolysis Reactions
- Oxidation Involving Air/Oxygen or Peroxides
- Nitrogen Rich Reactions Involving Azides or Hydrazine
- Photochemistry
- Flow Hydrogenation
- Flow Nitration
- Enzymatic Catalysis with Immobilized Enzymes
Large Scale (> 1 metric ton) Flow Chemistry Experience on Selected Reactions
Low Temperature
Metallo-Organic Reactions
- Deprotonation and Michael addition
- Lithiation and Methylation
High Temperature/
Pressure Reactions
- Cope Elimination
- Amination
Photochemistry
- Photo Halogenation
Oxidation
- Aerobic Oxidation
- Swern Oxidation
Others
- Amide Coupling
- Hydrogenation
- Cyanidation
Related Resource
Sustainable API Process Enabled by Continuous Manufacturing (Flow Chemistry)
Do you know the concrete benefits of using continuous manufacturing (flow chemistry) to address environmental concerns in your pharmaceutical API development? Watch this on-demand webinar co-presented by Benjamin Martin, Ph.D. Associate Director at Novartis, and Hongwei Yang, Ph.D., Executive Director at WuXi STA as they discuss case studies on solving the challenges faced during process R&D and scale-up and the use of sustainability metrics.
